Back to Blog
Neat escape hospital6/17/2023 ![]() ![]() In order to tackle the above questions, the authors performed the following studies using adult zebrafish as a model. 1 esV2a interneurons are recruited prior to pMNs and CoLo interneurons. The fundamental question in the field is whether excitatory V2a interneurons in the spinal cord participate in and determine the escape directionality induced by Mauthner cell activation.įig. Spinal excitatory V2a interneurons (expressing transcription factor Chx10) are considered to be glutamatergic neurons and set excitability and rhythmicity of the locomotion 3, 4. Interplay between excitatory and inhibitory interneurons in the spinal cord tranforms brain motor commands into locomotion rhythms and patterns, thus driving motor neurons and their innervated muscles to complete corresponding motor behaviors 1, 2. The transient motor commands from the brain activate the spinal neural circuit through the descending axon of reticulospinal neurons. Neural circuits in the spinal cental pattern generator generate and execute motor behaviors. In this study, the authors used zebrafish "brain-spinal cord" in vivo and in vitro preparations to specificly answer this question. However, whether the neural control mechanism underlying behavioral choice only originates from the "brain" or is jointly determined by the "brain-spinal cord" has been controversial for a long time. These studies introduced many important conceptional difinitions in the field of neurobiology, such as motor command neurons, asymmetric gap junctions, sensory-motor integration, etc. A neat escape circuit system including the Mauthner cells in the teleost fish has been used to study the neural mechanisms of behavioral choice since 1950s.
0 Comments
Read More
Leave a Reply. |